All articles tagged with #biocatalysis
Researchers at Caltech and the University of Pittsburgh have developed a new biocatalytic method to synthesize chiral oxazolidinones, key scaffolds in next-generation antibiotics, directly from unactivated alkenes using engineered haemproteins.
Researchers present REAP (Rank-guided Exploration for Automated enzyme reProgramming), a closed-loop AI-automation platform that uses a RankReg hybrid loss to learn from experimental feedback, enabling adaptive learning from single mutations to productive combinatorial variants. Applied to cytochrome P450 BM3 and SaSrtA, REAP achieved a 57-fold improvement in one case and up to 104-fold enhancement in the other, demonstrating a scalable, generalizable framework for fast biocatalyst discovery and enzyme-enabled synthesis.
Researchers developed EZSpecificity, a cross-attention graph neural network model, to accurately predict enzyme substrate specificity, outperforming existing models with a 91.7% accuracy in experimental validation, aiding biological and medical research.