Tag

Cardiolipin

All articles tagged with #cardiolipin

health-and-science10 days ago•87 min saved

Cardiolipin Decline Drives Muscle Fiber Shifts in Aging

A new study in Nature Aging reveals that the decline of the mitochondrial lipid cardiolipin is a primary driver of muscle fiber type changes during aging. By depleting this lipid in young mice, researchers reproduced age-related muscle shifts and found that restoring it reversed atrophy and improved survival. While this highlights internal cellular mechanisms, other recent research points to nerve-muscle communication failures as a separate, reversible cause of age-related weakness.

via Nature|

#aging #cardiolipin #health-and-science

science4 months ago•106 min saved

Cardiolipin deficiency in T cells disrupts gut tolerance through an ISR-driven Treg failure

In a mouse model, T cell–specific loss of cardiolipin synthesis (PTPMT1 deletion) impairs regulatory T cell (Treg) function, triggering a maladaptive integrated stress response (ISR) that disrupts gut immune homeostasis and predisposes to colitis, even without dysbiosis. The severity intensifies with pathobiont exposure and can be reversed by pharmacologic or genetic ISR blockade (ISRIB or CHOP knockout), which restores Treg identity and extends lifespan. These findings are echoed in Barth syndrome models and patient data, suggesting a cardiolipin–ISR mitonuclear axis as a key determinant of gut tolerance to microbiota and a potential therapeutic target for IEM-related gut inflammation.

via Nature|

#cardiolipin #gut-inflammation #integrated-stress-response