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Gut Inflammation

All articles tagged with #gut inflammation

Cardiolipin deficiency in T cells disrupts gut tolerance through an ISR-driven Treg failure
science9 days ago

Cardiolipin deficiency in T cells disrupts gut tolerance through an ISR-driven Treg failure

In a mouse model, T cell–specific loss of cardiolipin synthesis (PTPMT1 deletion) impairs regulatory T cell (Treg) function, triggering a maladaptive integrated stress response (ISR) that disrupts gut immune homeostasis and predisposes to colitis, even without dysbiosis. The severity intensifies with pathobiont exposure and can be reversed by pharmacologic or genetic ISR blockade (ISRIB or CHOP knockout), which restores Treg identity and extends lifespan. These findings are echoed in Barth syndrome models and patient data, suggesting a cardiolipin–ISR mitonuclear axis as a key determinant of gut tolerance to microbiota and a potential therapeutic target for IEM-related gut inflammation.

via Nature|
#cardiolipin#gut-inflammation#integrated-stress-response
"Uncovering the Gut-Brain Connection: How Gut Inflammation Impacts Alzheimer's Risk"
health2 years ago

"Uncovering the Gut-Brain Connection: How Gut Inflammation Impacts Alzheimer's Risk"

New research suggests a link between gut inflammation and Alzheimer's disease, with studies showing that Alzheimer's can be passed on to young mice through a transfer of gut microbes. People with Alzheimer's were found to have higher gut inflammation, which correlated with higher levels of amyloid plaque accumulation in their brains. Levels of calprotectin, a sign of inflammation, were higher in older patients and even more pronounced in those with Alzheimer's characteristic amyloid plaques. The study indicates that gut inflammation may play a role in the development of Alzheimer's, and researchers are now testing mice to see if diet changes associated with increased inflammation can trigger the rodent version of the disease.

via ScienceAlert|
#alzheimers-disease#brain-health#gut-inflammation
health2 years ago

"Linking Gut Health to Alzheimer's and Parkinson's: The Ageing Connection"

A study by the University of Wisconsin School of Medicine and Public Health suggests a link between gut inflammation and changes in the brain, memory decline, and Alzheimer’s disease, with higher levels of calprotectin associated with increased amyloid plaque in the brain. The research indicates that gut inflammation may be linked to neurodegenerative diseases, and ongoing studies are exploring the potential causality and impact of gut health on Alzheimer’s pathology. The findings highlight the functional connection between the gut and brain and may lead to further research on interventions such as probiotics to improve gut inflammation and potentially prevent cognitive decline associated with Alzheimer’s disease.

via University of Wisconsin School of Medicine and Public Health|
#aging#alzheimers-disease#brain-health