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Carotid Imt

All articles tagged with #carotid imt

science6 hours ago•9 min saved

Exercise amplifies cardiovascular gains from GLP-1 therapy beyond weight loss

Nature Metabolism’s News & Views previews Sandsdal, Holt et al.’s findings that exercise alone, or in combination with the GLP-1 receptor agonist liraglutide, improves cardiovascular health markers and reduces carotid intima-media thickness. Liraglutide without exercise preserves weight loss but yields fewer cardiovascular benefits than exercise, highlighting benefits beyond weight loss for GLP-1 therapies in cardiovascular disease.

via Nature|

#cardiovascular-disease #carotid-imt #exercise

health14 hours ago•28 min saved

Exercise drives vascular health during weight-loss maintenance; adding liraglutide offers no extra vascular benefit

In a prespecified secondary analysis of the S-LiTE trial, 130 adults with obesity completed a diet-induced weight loss phase and were randomized to 52 weeks of weight maintenance with placebo, exercise, liraglutide, or both. Exercise, alone or with liraglutide, reduced carotid intima-media thickness (cIMT) by about 7% and 6%, respectively, and lowered circulating inflammatory markers IL-6 and IFN-γ; the combination also improved endothelial biomarkers sICAM-1, sVCAM-1 and tPA. Liraglutide alone did not change cIMT or these biomarkers. Overall, regular physical activity appears essential for vascular health during weight loss maintenance, with GLP-1 receptor agonist therapy adding no extra vascular benefit in this setting.

via Nature|

#carotid-imt #exercise #health