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In vivo TRAC-CAR T cells engineered with dual vectors demonstrate potent cancer control
science24 days ago

In vivo TRAC-CAR T cells engineered with dual vectors demonstrate potent cancer control

Researchers report a dual-vector in vivo system that edits the TRAC locus in T cells by delivering Cas9 via enveloped delivery vehicles and HDR templates via AAV6 (AAV-hT7), enabling promoterless CAR insertion at TRAC and generation of TRAC-CAR T cells directly in humanized mice. The approach produced therapeutic levels of CAR T cells, induced B cell aplasia, and controlled tumors in models of B-ALL, multiple myeloma, and solid tumors, with improved specificity from anti-CD3-targeted EDVs and an evolved, serum-resistant AAV-hT7 capsid. This could bypass ex vivo manufacturing and enable broader access to CAR T therapies, though translational safety and durability remain to be fully evaluated in primate models.

via Nature|
#aavht7#cart#crispr-cas9
Trevor Lawrence's Injury Raises Concerns and Questions for Jaguars
sports2 years ago

Trevor Lawrence's Injury Raises Concerns and Questions for Jaguars

Jacksonville Jaguars quarterback Trevor Lawrence clarified that the team did have a cart available to transport him off the field after injuring his ankle, but he chose to walk with assistance instead. Lawrence explained that he wanted to quickly get off the field and didn't want to wait for the cart. He dismissed criticism of the team, stating that the Jaguars have all the necessary resources. Lawrence's ankle is healing well, and he hopes to be cleared to play in the upcoming game against the Cleveland Browns.

via ESPN|
#cart#injury#jacksonville-jaguars
San Francisco Officials Clash Over Controversial Drug Enforcement Policy
law-enforcement2 years ago

San Francisco Officials Clash Over Controversial Drug Enforcement Policy

San Francisco Police Chief Bill Scott faced questioning from police commissioners over the mayor's promise to arrest drug users and dealers through a recently announced unified command center. The center, called the Drug Market Agency Coordination Center, was established to crack down on "open-air drug markets," including arresting people publicly using drugs. The police department showed no signs of reversing course, but the Police Commission is experimenting with programs that might, including CART (the Compassionate Alternative Response Team), a non-police alternative program that would allow mental health and social workers, not officers, to respond to certain 911 and 311 calls.

via Mission Local|
#cart#drug-crackdown#law-enforcement