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Cml

All articles tagged with #cml

Merck to buy Terns to accelerate CML program with allosteric inhibitor TERN-701
business17 days ago

Merck to buy Terns to accelerate CML program with allosteric inhibitor TERN-701

Merck will acquire Terns Pharmaceuticals for about $6.7 billion in cash, expanding its hematology portfolio with TERN-701, an oral allosteric BCR-ABL1 inhibitor in Phase 1/2 for Philadelphia chromosome-positive chronic myeloid leukemia (CML). The transaction, approved by both boards, is expected to close in the second quarter of 2026 and will be accounted as an asset acquisition with an approximate $5.8 billion impact on 2026 GAAP/non-GAAP results. TERN-701 has shown encouraging early activity and carries FDA Orphan Drug Designation from 2024, underscoring its potential as a differentiated CML therapy.

via Merck.com|
#business#cml#hematology
Novartis' Scemblix Outperforms Standard Treatments in Phase III Leukemia Trial
health1 year ago

Novartis' Scemblix Outperforms Standard Treatments in Phase III Leukemia Trial

Novartis' Phase III ASC4FIRST trial shows that Scemblix® (asciminib) is more effective and has a better safety profile than standard-of-care tyrosine kinase inhibitors (TKIs) in treating newly diagnosed chronic myeloid leukemia (CML). Scemblix achieved higher major molecular response rates at week 48 compared to other TKIs and imatinib alone, with fewer adverse events and treatment discontinuations. The trial results have been submitted to the FDA for review, and Scemblix has been granted Breakthrough Therapy Designation.

via Novartis|
#clinical-trial#cml#fda