Enzyme Destroys AGE Waste in Tissues, Showing Ex Vivo Rejuvenation Clues
Scientists developed CMLase to break down N(6)-Carboxymethyllysine (CML), a damaging AGE that can impair tissue function. In ex vivo experiments, treating skin reduced CML by 55% and arterial tissue by 75%, suggesting AGE cleanup could improve tissue health, but safety and efficacy in living humans still need to be established through clinical trials.