Multi-omic Regulation of Cellular Senescence
Nature Reviews Genetics surveys how genomic, epigenomic and transcriptomic programs coordinate the induction, maintenance and heterogeneity of cellular senescence, highlighting the DNA damage response and non-genotoxic stress, epigenetic remodeling and SASP-driven intercellular signaling, while calling for next-generation biomarkers and single‑cell multi-omics approaches to accurately identify and target senescent cells.