Quetiapine Eases Sleep Apnea Yet Impairs Morning Driving
A small randomized trial in 15 adults with obstructive sleep apnea and sleep-maintenance difficulties found that taking 50 mg of quetiapine before bed increased total sleep time and reduced apnea events, but tripled morning attention lapses and worsened driving performance in a simulator. Researchers caution against driving for about 9.5 hours after dosing and note the study’s small size and single-night design, with sex-based differences in drug metabolism potentially influencing effects. Larger studies are needed to confirm the trade-offs between sleep benefits and daytime functioning.
