Tag

Endosome

All articles tagged with #endosome

Columbia Researchers Trace Alzheimer's Origins Inside Brain Cells, Paving Way for New Drugs
health1 month ago

Columbia Researchers Trace Alzheimer's Origins Inside Brain Cells, Paving Way for New Drugs

Columbia University researchers at the Alzheimer's Research Center are pinpointing where Alzheimer's starts by studying the brain cell's endosome, using mouse models and postmortem human brains to test whether correcting this defect can rescue brain cell function, with plans to translate findings into drugs through academia–industry collaboration over the coming years.

3D Lipid Mapping Uncovers Lipid Sorting in Early Endosomes
science5 months ago

3D Lipid Mapping Uncovers Lipid Sorting in Early Endosomes

A new Lipid-CLEM workflow combines photo-crosslinkable lipid probes with correlative light and electron microscopy to visualize lipid organization in membranes in 3D, revealing that sphingomyelin concentrates in small endosomal vesicles while avoiding tubular domains, indicating active lipid sorting in early endosomes and potential implications for membrane-related diseases.