Tag

Ezetimibe

All articles tagged with #ezetimibe

Very High LDL Triggers Aggressive Statin Therapy, Roach Says
health21 days ago

Very High LDL Triggers Aggressive Statin Therapy, Roach Says

In a health Q&A, Dr. Roach explains that an LDL over 190 mg/dL carries high cardiovascular risk, so statin therapy is recommended—even for younger patients—though the dose is debated. A patient on rosuvastatin 40 mg plus ezetimibe is reasonable, but many clinicians tailor dosing to reach LDL goals (often <70 mg/dL) by starting lower and titrating. In a second question, diet sodas can erode tooth enamel and may influence gut microbiome and future glucose control; they don’t reliably raise A1C in the short term, but water is best, with sugar-sweetened beverages worse for health.

Ultra-Low LDL Target (55 mg/dL) Cuts Events in ASCVD: Ez-PAVE
health5 months ago

Ultra-Low LDL Target (55 mg/dL) Cuts Events in ASCVD: Ez-PAVE

In the Ez-PAVE randomized trial of 3,048 ASCVD patients across 17 Korean sites, aiming for an intensive LDL target of <55 mg/dL vs a conventional <70 mg/dL reduced the 3-year composite of cardiovascular death, nonfatal MI, nonfatal stroke, revascularization, or unstable-angina hospitalization by 33% (HR 0.67). Intensive targeting achieved median LDL of 56 mg/dL vs 66 mg/dL, with higher use of ezetimibe and high‑intensity statins; safety was similar between groups. The findings, published alongside updated guidelines, support lower LDL goals in secondary prevention and note ezetimibe-first strategies as cost-effective before PCSK9 inhibitors. Notably, the benefit for women was not evident, likely due to limited power.