Tag

Finerenone

All articles tagged with #finerenone

health16 days ago•11 min saved

Finerenone extends kidney protection to non-diabetic CKD, early FIND-CKD data show

Finerenone, a nonsteroidal mineralocorticoid receptor antagonist, continues to show kidney and cardiovascular benefits in chronic kidney disease, with FIND-CKD data indicating protection even in patients without diabetes; however, there is a modest rise in serum potassium (about 0.12 mmol/L) and hyperkalemia events occurred in 17% of treated patients versus 13.3% in placebo, overall suggesting good safety and tolerability.

via Nature|

#chronic-kidney-disease #find-ckd #finerenone

health1 month ago•7 min saved

Finerenone Extends Kidney Disease Benefits to Non-Diabetic Patients

A NEJM-identified FIND-CKD trial shows finerenone, previously used for diabetic CKD, also slows kidney function decline in adults with CKD who do not have diabetes. In 1,584 non-diabetic participants, finerenone added to standard therapy (ACE inhibitors/ARBs) significantly slowed eGFR loss over about 2.5 years and reduced the risk of major kidney events, heart failure hospitalization, and cardiovascular death by roughly 23%, while also lowering urinary protein by over 40%. The drug was well tolerated, suggesting it could broaden treatment to the roughly 800 million non-diabetic CKD patients worldwide.

via SciTechDaily|

#chronic-kidney-disease #find-ckd #finerenone

health2 years ago•1 min saved

Improving Kidney and Heart Function in Type 2 Diabetes Through Albumin Reduction

Reducing the urine albumin-to-creatinine ratio (UACR) through the use of finerenone significantly reduces kidney and cardiovascular risk in people with type 2 diabetes. A study found that a UACR reduction of at least 30% led to a 64% reduction in kidney risk and a 26% reduction in cardiovascular risk. Achieving early UACR reduction can have tangible benefits for kidney and cardiovascular health. However, the study only pertains to finerenone and cannot be extrapolated to other drugs with different mechanisms of action.

via Medscape|

#finerenone #health #heart-health