Evo 2: An Open-Source AI for Genome-Scale Prediction and Design Across Life
Evo 2 is a large, open biological foundation model trained on 9 trillion base pairs across all life, with a 1‑million‑token context, available in 7B and 40B sizes. It predicts mutational effects on DNA, RNA and proteins without task-specific fine-tuning, can generate genome-scale sequences and chromatin-accessibility designs, and supports exon–intron annotation and variant-effect prediction across diverse species. The model and data (OpenGenome2) are fully open-source, with training/inference code and tools (Evo Designer, Evo Mech Interp), plus safety safeguards such as virus-data exclusions to mitigate misuse.
