Tag

Growth Hormone Receptor

All articles tagged with #growth hormone receptor

science1 month ago•45 min saved

Ancient Neanderthal Variant Promotes Extra Muscle in Some Modern Humans

A Neanderthal variant of the growth hormone receptor (GHR) in modern humans boosts growth hormone signaling, with cells showing ~40% faster growth after hormone exposure and carriers gaining about 270 g more muscle on average. The variant's frequency varies by population (rare in Europeans, higher in parts of South and East Asia; ~24% in a Pakistani cohort). The effect appears during puberty rather than birth, contributing to a stockier build but not fully explaining Neanderthal anatomy; nearby genetic differences may also influence the traits.

via Archaeology News Online Magazine|

#genetics #growth-hormone-receptor #muscle-mass

science1 month ago•54 min saved

Ancient Neanderthal gene variant boosts muscle growth in a subset of people

A Cell study shows a Neanderthal variant of the growth hormone receptor entered the modern human gene pool about 47,000 years ago, boosting how cells respond to growth hormone. People with one copy may gain around 270 grams of extra muscle per copy, while two copies could add over 0.5 kg (about 1.2 pounds). The variant now appears in roughly 10% of people, with higher frequencies in Southern and Southeast Asian populations and little to none in those of African ancestry. It may also subtly affect jaw shape and tooth roots, and effects seem to emerge during puberty when growth hormone rises, indicating it's not the sole reason Neanderthals were robust but a piece of the puzzle.

via Yahoo|

#gene-variant #growth-hormone-receptor #interbreeding

anthropology2 months ago•8 min saved

Ancient Neanderthal Variant Still Shapes Muscles and Jaws in Modern Humans

A study comparing modern and Neanderthal genomes found a Neanderthal variant of the growth hormone receptor that enhances growth signaling and persists in non-African populations, especially in some South and East Asian groups where about 20% carry it. Carriers tend to be taller and heavier due to increased muscle mass, and exhibit Neanderthal-like jaw traits (shorter mandibular ramus, higher overbite, shorter tooth roots). Effects emerge around puberty, with lab experiments showing faster cell growth and stronger signaling in cells with the Neanderthal receptor. The variant is one of many factors influencing body shape and is not the sole determinant of the modern human physique.

via Sci.News|

#anthropology #genetics #growth-hormone-receptor

genetics2 months ago•5 min saved

Ancient Neanderthal DNA Linked to Subtle Height and Muscle Gains in Modern Humans

Researchers traced two amino-acid changes in the Neanderthal version of the growth hormone receptor, which likely entered modern human genomes through interbreeding about 47,000 years ago. In large biobank analyses (over 1.1 million adults), carriers of this Neanderthal-derived variant are on average about 0.3 cm taller and have about 0.25 kg more muscle mass than non-carriers; the variant is common in South Asia (~20%) and East Asia (~15%), but rare in Europe and absent in sub-Saharan Africa. Laboratory tests with mouse cells showed the Neanderthal receptor promotes more cell growth, supporting a molecular pathway for the observed physical differences.

via Nature|

#genetics #growth-hormone-receptor #height