
Ancient mating bias reshapes modern DNA: Neanderthal men, modern women
New research from the Tishkoff lab shows that Neanderthal DNA on the human X chromosome is surprisingly scarce, while modern-human DNA is enriched on Neanderthal X chromosomes by about 62% compared with their other chromosomes. This pattern points to sex-biased interbreeding where Neanderthal males mated with anatomically modern human females, shaping the modern genome more through mating dynamics than simple genetic incompatibility. Published in Science, the findings suggest ancient social patterns left a lasting imprint on our DNA and offer new insight into human evolution.













