Blocking a Second Signal Reveals New Path to Calm Gut Inflammation
Researchers at Weill Cornell Medicine show that blocking the gut Signal Two co-stimulation, rather than activating it, boosts RORγt+ regulatory T cells and reduces intestinal inflammation in a preclinical model, a paradigm-shifting finding with potential new treatments for inflammatory bowel disease and possibly other autoimmune conditions; the work also helps explain past abatacept (CTLA4-Ig) results and suggests strategies to restore RORγt+ APCs to make this approach effective.
