New Microscope Platform Unifies High-Resolution Imaging Across Diverse Biological Scales
Researchers have introduced the multi-immersion oblique plane microscope (miOPM), a versatile light-sheet fluorescence microscopy platform designed to overcome the fragmentation of current imaging systems. By utilizing a novel 'any immersion remote focusing' framework and a tunable zoom lens, miOPM allows users to interchange oil, water, and air objectives while maintaining diffraction-limited performance across a wide range of refractive indices. This adaptability enables high-resolution imaging of subcellular dynamics, whole organisms, and cleared tissues within a single instrument, potentially democratizing advanced 3D imaging capabilities.