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Hiv Drug

All articles tagged with #hiv drug

businesshealthcare2 years ago•1 min saved

Gilead's Stock Plummets on Disappointing Lung Cancer Study Results

Gilead Sciences Inc's stock is falling after its Phase 3 EVOKE-01 study evaluating Trodelvy in previously treated metastatic non-small cell lung cancer did not meet its primary endpoint of overall survival. Despite a numerical improvement in overall survival favoring Trodelvy, the study did not show a statistically significant difference. Gilead plans to discuss the results with regulators and explore potential pathways to understand Trodelvy's role in these patients. Trodelvy is the first approved Trop-2-directed antibody-drug conjugate that has shown meaningful survival advantages in metastatic breast cancers and improved clinical outcomes for certain people with metastatic urothelial cancer.

via Yahoo Finance|

#businesshealthcare #cancer-treatment #clinical-trial

health3 years ago•4 min saved

Maraviroc: A Promising Treatment for Dementia and Huntington's Disease.

Researchers at the University of Cambridge have found that an existing HIV drug, maraviroc, can inhibit a switch (CCR5) that impairs autophagy, leading to a reduction in harmful protein build-up and potentially slowing down memory loss in mice with Huntington's disease and dementia. The drug reduced the amount of tau aggregates and slowed down the loss of brain cells in dementia mice, and reduced the number of huntingtin aggregates in Huntington's disease mice. The discovery has led to clues on how this build-up could be slowed or prevented in humans.

via SciTechDaily|

#autophagy #dementia #health

health3 years ago•4 min saved

HIV Drug Shows Promise in Treating Dementia and Alzheimer's Disease.

A HIV drug called maraviroc has shown promise in clearing out toxic proteins that lead to Huntington's disease and a type of dementia in mice. The drug has been found to restore the brain's ability to clear out protein clusters, reduce brain cell death, and slow down memory loss in mice genetically engineered to have dementia. The research identifies a biological pathway that leads to neurodegeneration and a potential way to stop it. However, it is still too early to say whether the drug can prevent dementia or Huntington's in humans.

via ScienceAlert|

#autophagy #dementia #health