Arc protein may ferry toxic Tau between neurons, unveiling a new Alzheimer’s therapeutic target
Mouse studies show Arc enables toxic Tau to spread between neurons via extracellular vesicles; removing Arc dramatically reduces Tau transfer, but Arc also helps neurons expel Tau, suggesting therapies should target the Tau-containing vesicles rather than Tau itself—offering a potential new route to slow Alzheimer's progression, though human relevance remains to be proven.