Arc protein may ferry toxic Tau between neurons, unveiling a new Alzheimer’s therapeutic target
TL;DR
Mouse studies show Arc enables toxic Tau to spread between neurons via extracellular vesicles; removing Arc dramatically reduces Tau transfer, but Arc also helps neurons expel Tau, suggesting therapies should target the Tau-containing vesicles rather than Tau itself—offering a potential new route to slow Alzheimer's progression, though human relevance remains to be proven.
Topics:healthhealth-and-medicine#alzheimers-disease#arc-protein#extracellular-vesicles#health-and-medicine#intercellular-transmission#tau-protein
- Scientists may have finally found how Alzheimer's spreads through the brain ScienceDaily
- Arc Protein Found to Spread Toxic Tau in Alzheimer’s Neuroscience News
- Brain Messenger Protein May Help Tau Spread in Alzheimer’s Disease Inside Precision Medicine
- How A Rogue Tau Protein Drives Destruction — and How it Might be Stopped | Newswise Newswise
- How a Brain Messenger Protein Drives Progression of Alzheimer’s Disease University of Utah Health
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