All articles tagged with #extracellular vesicles
Mouse studies show Arc enables toxic Tau to spread between neurons via extracellular vesicles; removing Arc dramatically reduces Tau transfer, but Arc also helps neurons expel Tau, suggesting therapies should target the Tau-containing vesicles rather than Tau itself—offering a potential new route to slow Alzheimer's progression, though human relevance remains to be proven.
Texas A&M researchers report that a two-dose intranasal spray delivering extracellular vesicles loaded with microRNAs reduced brain inflammation, restored mitochondrial function, and improved memory in animal models—hinting at a potential, noninvasive therapy for age-related cognitive decline and dementia, though human trials are not yet underway and findings are preclinical.
Texas A&M researchers report that a two-dose intranasal spray delivering extracellular vesicles with microRNAs reduced brain inflammation, recharged neuronal mitochondria, and noticeably improved memory in preclinical aging models, suggesting a noninvasive therapy for brain aging and dementia that bypasses the blood-brain barrier; the team has filed a US patent with backing from the National Institute on Aging.
A two-dose intranasal spray of extracellular vesicles from human stem cells reduced brain inflammation and restored memory in aged mice, suggesting a noninvasive approach to age-related cognitive decline, though human trials are needed to assess applicability to dementia.
Texas A&M researchers report a two-dose nasal spray that uses microRNA-loaded extracellular vesicles to bypass the blood-brain barrier, reduce neuroinflammation, and restore cognitive function in aging animal models within weeks — with effects lasting months and observed in both sexes. Human trials are years away; the team has filed a patent and has backing from the National Institute on Aging, though safety details remain undisclosed.
A preclinical mouse study reports a nasal spray that delivers extracellular vesicles containing microRNAs to the brain can reverse signs of brain ageing within weeks, lowering inflammation and boosting cognitive processing. Two doses showed benefits, suggesting the brain’s repair systems can be reactivated, but more research and human trials are needed.
Two-dose intranasal spray delivering extracellular vesicle microRNA cargo reduced brain inflammation, recharged mitochondrial function, and significantly improved memory in aging brain models within weeks—effects lasting months—which could reshape neurodegenerative therapies and offer a noninvasive alternative to invasive procedures or long-term meds, with a U.S. patent filed.
A Texas A&M–led study reports a non-invasive intranasal spray carrying extracellular vesicles and microRNA cargo can reach the brain, suppress chronic inflammation, recharge mitochondrial function, and markedly improve memory in aging models within weeks—effects persist for months after just two doses and are similar in males and females. The researchers envision potential use in stroke recovery and dementia therapy, and a U.S. patent has been filed.
Researchers found that cancer cells load the immune-inhibiting protein PD-L1 into tiny extracellular vesicles via the protein UBL3, helping tumors suppress immune responses. Statins block this UBL3-driven modification, reducing PD-L1 cargo and potentially improving responses to immune checkpoint inhibitors, with supporting evidence from non-small cell lung cancer patients showing fewer PD-L1–containing vesicles in those taking statins.
Researchers are investigating how cancer uses extracellular vesicles to colonize new organs and are creating artificial liposomes that mimic these vesicles to observe uptake by cancer cells in real time, with the goal of delivering targeted therapies and ultimately blocking metastasis while improving drug delivery.
A Tel Aviv University study reveals that melanoma cells release extracellular vesicles that disable immune cells, providing new insights that could lead to improved treatments for skin cancer.
Research from Touro University reveals that vigorous exercise increases extracellular vesicles in the blood that transport hormone precursors like POMC more efficiently across biological barriers, including the blood-brain barrier, potentially impacting stress, mood, metabolism, and drug delivery.
Columbia scientists developed a yogurt-derived, injectable healing gel that promotes tissue regeneration by utilizing extracellular vesicles from milk, demonstrating promising results in mouse models for blood vessel formation and tissue repair without added chemicals.
Nearly one-third of Americans are infected with Toxoplasma gondii, a parasite that silently alters brain function by disrupting neuron-astrocyte communication through changes in extracellular vesicles, potentially increasing risks for neurological disorders and offering new avenues for detection and treatment.
New research shows that the brain parasite Toxoplasma gondii disrupts neuron communication by reducing extracellular vesicle signaling, which may contribute to neurological and behavioral conditions; detection and treatment strategies are being explored.