Tag

Jq1

All articles tagged with #jq1

Meiosis-Blocking Drug Shows Non-Hormonal Path to Male Birth Control in Mice
science2 days ago

Meiosis-Blocking Drug Shows Non-Hormonal Path to Male Birth Control in Mice

Cornell researchers showed that the non-hormonal drug JQ1 can temporarily halt sperm production by blocking meiosis in male mice, with fertility returning and offspring normal after stopping treatment. While JQ1 itself is unlikely to be developed due to side effects and short half-life, the study provides a proof of concept for non-hormonal male birth control and underscores multiple other candidates and approaches in the field seeking long-lasting, non-hormonal options.

Meiosis-Targeted Breakthrough Moves Toward Reversible Nonhormonal Male Contraception
science3 days ago

Meiosis-Targeted Breakthrough Moves Toward Reversible Nonhormonal Male Contraception

Cornell researchers in mice used the small molecule JQ1 to block meiosis at prophase 1, halting sperm production for three weeks with fertility and normal offspring restored within six weeks after stopping treatment, providing a proof of principle for a safe, reversible, nonhormonal male contraceptive; the team plans to pursue additional meiosis targets and aim to develop a long-acting delivery method (injection or patch) and even launch a company to advance these candidates.