Stanford unveils 120-nm, label-free microscope for real-time live-cell imaging
Stanford researchers developed Interferometric Image Scanning Microscopy (iISM), a label-free instrument that reaches ~120-nanometer resolution inside living cells by merging interferometric scattering with array-based detection, enabling real-time observation of cellular structures with less light and no fluorescent labels. It complements fluorescence microscopy and opens new avenues for studying pathogen interactions, drug entry, and malaria-related cell changes, with plans to broaden access and collaborations.