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Lacosamide

All articles tagged with #lacosamide

science-and-health2 days ago•3 min saved

Yale Study Finds Epilepsy Drug Lacosamide May Reverse Osteoarthritis via Targeted Hydrogel Delivery

Yale researchers discovered that lacosamide, an FDA-approved epilepsy medication, can simultaneously reduce pain and repair cartilage in osteoarthritis when delivered via a specialized hydrogel. The study, published in Bioactive Materials, identifies the Nav1.7 protein as a dual target for both pain signaling and cartilage degradation. By using a temperature-sensitive collagen hydrogel to keep the drug localized in the joint, the treatment outperformed daily oral doses in preclinical tests, offering a potential path to disease modification rather than just symptom management.

via ScienceDaily|

#drug-repurposing #hydrogel-delivery #lacosamide

health1 month ago•5 min saved

Lacosamide Could Turn Osteoarthritis Treatment from Pain Relief to Cartilage Repair

Yale researchers repurposed lacosamide, an FDA-approved epilepsy drug, with a collagen II hydrogel delivered directly into the knee to simultaneously relieve pain and reverse cartilage damage in osteoarthritis. They show Nav1.7 drives both pain and cartilage breakdown in chondrocytes, and, at a precise low dose, lacosamide boosts cartilage-building proteins while triggering protective signals (HSP70 and midkine). The hydrogel enables weeks-long, localized drug release, outperforming daily oral dosing in preclinical tests, suggesting a faster path to human trials since the drug is already approved.

via SciTechDaily|

#cartilage-repair #health #hydrogel