Soil megacluster yields multi-target antibiotics against biotin biosynthesis
Researchers identified a megacluster of biosynthetic genes in Streptomyces that encodes four antibiotics—stravidins, acidomycin, α-Me-KAPA, and dapamycins—plus the biotin‑targeting protein streptavidin, all aimed at blocking vitamin B7 (biotin) production at different steps, a multi‑pronged approach that could slow resistance and guide new antibiotic development.