All articles tagged with #mice model
A Nature study in mice shows that gut microbiome composition, especially Muribaculaceae abundance, correlates with sepsis severity: mice with higher gut bacterial load exhibit a stronger early inflammatory response and more bacteria in blood and organs, suggesting the microbiome may signal immune reactions before infection and that antibiotic-induced dysbiosis could worsen outcomes; human trials are needed.
A triple-drug regimen that targets three cancer-growth pathways—KRAS, its related pathway, and STAT3—completely eradicated pancreatic tumors across three mouse models, prevented tumor recurrence for about seven months, and showed no significant toxicity in mice. The treatment uses afatinib, daraxonrasib, and a novel STAT3 inhibitor. While the results are promising, researchers caution that mouse findings may not translate to humans and plan further drug development and clinical testing across diverse KRAS mutations.