Gut Microbes Signal Parkinson’s Risk Years Before Symptoms
A multi-cohort study finds a distinctive gut microbiome signature that distinguishes people with Parkinson’s and healthy individuals at genetic risk (including GBA1 carriers without symptoms), suggesting the gut microbiome could serve as an early warning and preventive target. Findings replicated across UK, Korea, and Turkey with over 1,400 participants; diet diversity may influence risk, and UCL-led trials are testing gut-targeted therapies, including using a common cough medicine, to slow progression.