All articles tagged with #nerve injury
Cancer-induced nerve injury (CINI) promotes resistance to anti-PD-1 therapy by causing myelin degradation and chronic inflammation, which leads to immune exhaustion. The study shows that nerve injury within tumors correlates with immunosuppressive activity and therapy resistance across multiple cancer types, and that blocking nerve injury signaling can improve immune response and treatment efficacy.
Scientists from the Universities of Sheffield, Reading, and University College London, along with US-based biopharmaceutical company Neuresta, have developed an elongated botulinum neurotoxin that can alleviate chronic pain without causing addiction or nerve damage leading to paralysis. The new drug provides long-lasting relief in mice models without adverse effects and could potentially relieve pain for many months in humans. The team hopes that the engineered drug could improve the quality of life for the millions of people worldwide who suffer from chronic pain.