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Cancer Immunotherapy

All articles tagged with #cancer immunotherapy

Personalized mRNA Melanoma Vaccine Extends Recurrence-Free Survival in Phase 3
health8 days ago

Personalized mRNA Melanoma Vaccine Extends Recurrence-Free Survival in Phase 3

Moderna and Merck reported Phase 3 results for intismeran autogene (a personalized mRNA cancer vaccine) combined with Keytruda in high-risk melanoma patients after surgery, showing longer recurrence-free and metastasis-free survival versus Keytruda alone; safety was consistent with prior data. If confirmed, the vaccine could reshape cancer prevention and treatment and bolster mRNA vaccine credibility, but overall survival results and external validation are still pending.

via Gizmodo|
#cancer-immunotherapy#clinical-trials#fda-approval
Personalized mRNA cancer vaccine clears Phase 3 hurdle in melanoma
health10 days ago

Personalized mRNA cancer vaccine clears Phase 3 hurdle in melanoma

A patient-specific mRNA vaccine (intismeran autogene) combined with Keytruda met the Phase 3 primary endpoint in a 1,137-patient trial of resected melanoma, improving recurrence-free survival and potentially paving the way for the first FDA-approved mRNA-based cancer therapy; full data are to be presented later, with safety profile consistent with Keytruda.

via washingtonpost.com|
#cancer-immunotherapy#health#keytruda
Two-target antibodies sharpen cancer attack, enabling even more complex multispecific therapies
science25 days ago

Two-target antibodies sharpen cancer attack, enabling even more complex multispecific therapies

Bispecific antibodies that bind two targets are rapidly moving into the clinic and becoming more elaborate, with the number of approved drugs rising from 3 to over 20 in five years and 2025 sales around $18 billion. Most work as T cell engagers that recruit immune cells to cancer, but researchers are developing multispecifics that target three or more components to boost efficacy, reduce toxicity to healthy cells, and counter resistance. Advances in protein production and AI are enabling these complex designs, signaling a shift toward smarter, more selective cancer therapies.

via Nature|
#biotech#bispecific-antibodies#cancer-immunotherapy
Creatine as Immune Fuel: A New Route to Boost Cancer Immunotherapy
science1 month ago

Creatine as Immune Fuel: A New Route to Boost Cancer Immunotherapy

A UCLA-led study shows creatine can power dendritic cells and killer T cells to attack cancer, potentially enhancing immunotherapies. In human cells and mouse tumor models, higher creatine transport into dendritic cells correlated with stronger T-cell activation, and boosting creatine slowed tumor growth in mice. The findings are preliminary (cell culture and animal work) and clinical trials are planned; patients should not self-administer creatine to treat cancer without a doctor.

via ScienceAlert|
#cancer-immunotherapy#creatine#dendritic-cells
Creatine May Bolster Cancer-Fighting Immunity, Early Lab Results Suggest
science1 month ago

Creatine May Bolster Cancer-Fighting Immunity, Early Lab Results Suggest

A UCLA-led study found that creatine supports dendritic cells, which activate T cells to attack cancer. Creatine transport into cells increases energy (ATP); creatine deficiency impaired dendritic cell activity and T-cell responses in mice. In mice, daily creatine injections slowed tumor growth and boosted dendritic cell infiltration; in human cells, creatine enhanced dendritic cell activation and their ability to stimulate T cells against cancer targets. The researchers propose creatine could augment immunotherapies and improve dendritic cell–based vaccines, but caution that results are early and human effects are not yet proven; consult doctors before starting any supplement.

via Medical News Today|
#cancer-immunotherapy#creatine#dendritic-cells
Creatine May Supercharge Immune Attack on Cancer
science1 month ago

Creatine May Supercharge Immune Attack on Cancer

UCLA researchers found creatine boosts dendritic cell activity and energy, enhancing the immune system's ability to activate killer T cells against tumors; in mice and human cells, creatine slowed melanoma growth and improved dendritic cell vaccines, suggesting potential to strengthen cancer immunotherapy, though human trials are still needed and safety considerations apply.

via ScienceDaily|
#cancer-immunotherapy#creatine#dendritic-cells
Cancer's Escape Trick May Backfire, Unlocking a New Immune Attack
health-and-medicine2 months ago

Cancer's Escape Trick May Backfire, Unlocking a New Immune Attack

Scientists found that when cancer cells reduce MHC I to dodge killer CD8+ T cells, they become more vulnerable to CD4+ T cells, which trigger ferroptosis. This reveals a surprising cross-talk in the immune system, challenging a long-held immunology principle and suggesting new approaches to cancer immunotherapy and bone marrow transplantation by leveraging CD4+ T cell activity against tumors and allogeneic targets.

via ScienceDaily|
#bone-marrow-transplantation#cancer-immunotherapy#cd4-t-cells
MHC I loss unlocks CD4+ T cell attack via ferroptosis in cancer
science3 months ago

MHC I loss unlocks CD4+ T cell attack via ferroptosis in cancer

Lowering MHC I on cancer cells makes them more susceptible to ferroptosis driven by CD4+ T cells, revealing that the MHC I pathway can support CD4+ T cell–mediated immunity and challenging the classic CD4+/CD8+ division; these findings could guide new immunotherapies and bone marrow transplant strategies, especially for tumors that escape CD8+ T cell responses.

via SciTechDaily|
#cancer-immunotherapy#cd4-t-cells#ferroptosis
3D Imaging Reveals How Killer T Cells Attack Cancer Inside Tumors
science3 months ago

3D Imaging Reveals How Killer T Cells Attack Cancer Inside Tumors

Researchers used cryo-expansion microscopy to preserve near-native cell structure and visualize cytotoxic T lymphocytes at the immune synapse in 3D, revealing a dome-shaped contact interface and variations in cytotoxic granules. Extending the technique to human tumor tissues, the team could observe T cells infiltrating tumors and deploying their killing machinery at nanometer-scale resolution, offering insights that could guide improvements in immuno-oncology therapies.

via SciTechDaily|
#cancer-immunotherapy#cryo-expansion-microscopy#cytotoxic-t-lymphocytes
Thymus: The aging immune regulator linked to longevity and cancer therapy
science3 months ago

Thymus: The aging immune regulator linked to longevity and cancer therapy

Scientists are reframing the thymus—a two-lobed gland behind the breastbone—as a central regulator of aging and immune health, with healthier thymuses linked to longer lifespans, lower cancer and heart-disease risk, and better responses to cancer immunotherapy; researchers are pursuing thymus rejuvenation and engineered thymic tissue to boost vaccines and transplant tolerance.

via Yahoo|
#aging#cancer-immunotherapy#immune-system
business4 months ago

Lilly to Acquire Kelonia for Up to $7B to Advance In Vivo CAR-T Therapy

Eli Lilly agreed to acquire Kelonia Therapeutics for up to $7 billion, with $3.25 billion upfront and the rest tied to milestones, in a deal expected to close in the second half of 2026. Kelonia’s in vivo CAR-T technology aims to reprogram patients’ T-cells inside the body to attack cancer, potentially offering a one-time IV therapy compared with traditional ex vivo CAR-T. Lilly plans to apply the tech beyond multiple myeloma to other blood cancers and possibly solid tumors, as part of a broader push to diversify beyond obesity and diabetes drugs amid ongoing biotech dealmaking and competition from J&J and Gilead-backed therapies.

via CNBC|
#business#cancer-immunotherapy#eli-lilly