Tag

Neuropixels

All articles tagged with #neuropixels

Same Brain Data, Varied Conclusions: 18 Teams Clash on Ripples
science12 hours ago

Same Brain Data, Varied Conclusions: 18 Teams Clash on Ripples

Eighteen teams analyzed the same Neuropixels dataset and largely disagreed on ripple density across brain areas, despite using defensible methods. The divergence arose from differences in how concepts were defined, which algorithms were used, and the parameters chosen, revealing substantial analytical variability. The effort spurs the CON²PHYS project to quantify conceptual disagreement and push for transparency, reference pipelines, and reporting standards to ensure conclusions are robust to analytical choices.

Two opposing neural populations drive brain-wide blood flow across arousal states
science1 month ago

Two opposing neural populations drive brain-wide blood flow across arousal states

A brain-wide study using functional ultrasound imaging (fUSI) and Neuropixels reveals two opposing neural populations—Arousal+ neurons that ramp up with arousal/whisking and Arousal− neurons that ramp down—that together shape brain-wide blood-volume fluctuations. Each population has a distinct haemodynamic response, and their combined activity predicts blood volume across brain regions and states better than bulk firing alone, with both populations present in every region. This two-population model reconciles regional and state differences in neurovascular coupling and accounts for brain-wide blood-flow changes during arousal and sensory-driven activity.