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Nmda Receptor

All articles tagged with #nmda receptor

science12 days ago•44 min saved

Alzheimer's death switch found, scientists halt it in mice with FP802

Researchers at Heidelberg University have identified a toxic complex formed by NMDA receptors and TRPM4 in the brain that they describe as a death switch driving neuron death in Alzheimer's disease. In mice, they used FP802, a TwinF Interface Inhibitor, to disrupt this complex, which slowed cognitive decline, preserved dendrites and synapses, and reduced amyloid plaques. The findings suggest a new therapeutic approach that targets the death switch rather than amyloid buildup, but human trials are not yet underway and results are limited to animal studies. Development with FundaMental Pharma is progressing toward potential clinical testing.

via Yahoo Creators|

#alzheimers-disease #death-switch #fp802

science18 days ago•3 min saved

Brain 'death switch' linked to Alzheimer's progression could be blocked by FP802

Researchers at Heidelberg and Shandong University identified a toxic interaction between NMDA receptors and the TRPM4 channel—described as a 'death complex'—that worsens Alzheimer’s in a mouse model. They showed FP802, a novel neuroprotective drug, can block this interaction, slowing neurodegeneration, preserving synapses and mitochondria, and reducing amyloid deposits, offering a therapeutic approach distinct from amyloid removal. While promising, further pharmacological development, toxicology work, and clinical trials are needed before it could be used in humans, and researchers are also exploring potential ALS applications.

via New York Post|

#alzheimers-disease #fp802 #neurodegeneration

science23 days ago•6 min saved

Mutant grin2a reveals thalamocortical circuit linked to cognitive deficits in schizophrenia

MIT researchers link a grin2a gene mutation to impaired updating of beliefs in mice via disruption of a mediodorsal thalamus–prefrontal cortex circuit, slowing adaptive decision-making; optogenetic activation of the circuit reversed the behavioral deficits, suggesting circuit-based targets for cognitive symptoms in schizophrenia.

via MIT News|

#grin2a #mediodorsal-thalamus #neuroscience

artificial-intelligence2 years ago•3 min saved

"AI's Memory Capabilities Mirror the Human Brain"

Researchers have discovered a striking similarity between AI memory processing in the Transformer model and the memory functions of the human brain's hippocampus. The study found that the Transformer model employs a gatekeeping process similar to the brain's NMDA receptor, which is crucial for memory consolidation. This research not only advances the development of Artificial General Intelligence (AGI) but also deepens our understanding of human memory mechanisms. The findings offer potential for developing more efficient, brain-like AI systems and shed light on the workings of the human brain through AI models.

via Neuroscience News|

#ai-memory-processing #artificial-intelligence #memory-consolidation

artificial-intelligence2 years ago•3 min saved

AI's Memory: A Mirror of the Human Brain

Researchers have discovered a striking similarity between the memory processing of artificial intelligence (AI) models, specifically the Transformer model, and the hippocampus of the human brain. By applying principles of human brain learning, the team found that the Transformer model uses a gatekeeping process similar to the brain's NMDA receptor, which facilitates memory formation. Mimicking the NMDA receptor's gating process in the Transformer model led to enhanced memory, suggesting that AI models can learn using established knowledge in neuroscience. This research opens up possibilities for developing low-cost, high-performance AI systems that learn and remember information like humans, while also providing valuable insights into the workings of the brain through AI models.

via Tech Xplore|

#ai #artificial-intelligence #memory-consolidation