Tag

Grin2a

All articles tagged with #grin2a

Mutant grin2a reveals thalamocortical circuit linked to cognitive deficits in schizophrenia
science22 days ago

Mutant grin2a reveals thalamocortical circuit linked to cognitive deficits in schizophrenia

MIT researchers link a grin2a gene mutation to impaired updating of beliefs in mice via disruption of a mediodorsal thalamus–prefrontal cortex circuit, slowing adaptive decision-making; optogenetic activation of the circuit reversed the behavioral deficits, suggesting circuit-based targets for cognitive symptoms in schizophrenia.

Scientists Identify Gene Linked to Mental Illness and Potential Treatment Target
health3 months ago

Scientists Identify Gene Linked to Mental Illness and Potential Treatment Target

Scientists have discovered that mutations in the GRIN2A gene can cause serious mental illnesses like schizophrenia and depression, often starting in childhood. This breakthrough suggests that genetic testing could identify individuals at risk and that targeted treatments, such as L-serine supplements, may help manage or even cure these conditions, offering hope for personalized mental health care.