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Murakami's late homer lifts Sox to Detroit sweep
white-sox-game-recaps19 days ago

Murakami's late homer lifts Sox to Detroit sweep

Trailing 4-1 in Detroit, the White Sox rallied with five unanswered innings a la Romo’s fifth-inning two-run homer and Grichuk-Montgomery's sixth-inning go-ahead rally to tie the game at 4. Munetaka Murakami then delivered a seventh-inning two-run blast and Miguel Vargas added an insurance run in the ninth as Chicago held on for a 7-5 win, completing a three-game sweep at Comerica Park—their first in Detroit since 2022 and with their AL Central lead extending to 5.5 games (magic number down to 34).

via Sox Machine|
#good-bullpen#hsmith-gem#long-save
FDA Grants Accelerated Approval for KRESLADI to Treat Pediatric LAD-I
healthcare5 months ago

FDA Grants Accelerated Approval for KRESLADI to Treat Pediatric LAD-I

Rocket Pharmaceuticals announced that the FDA granted accelerated approval for KRESLADI (marnetegragene autotemcel), an autologous hematopoietic stem cell–based gene therapy for pediatric patients with severe LAD-I due to ITGB2 variants who lack an HLA-matched donor. Approval is based on increased neutrophil CD18/CD11a expression and will rely on longer-term follow-up data and a post‑marketing registry to confirm benefit. The FDA also awarded Rocket a Rare Pediatric Disease Priority Review Voucher, which the company plans to monetize. LAD-I is ultra-rare and causes recurrent life-threatening infections; safety concerns include infections during conditioning, veno-occlusive disease, engraftment failure, potential insertional oncogenesis, hypersensitivity, anti-retroviral interactions, and possible HIV test false positives, necessitating long-term monitoring. A conference call is planned for March 27, 2026.

via Business Wire|
#fda-approval#gene-therapy#healthcare