Tag

Phage

All articles tagged with #phage

AI designs 16 novel viruses from DNA patterns learned across trillions of nucleotides
science3 hours ago

AI designs 16 novel viruses from DNA patterns learned across trillions of nucleotides

Researchers trained Evo, a genomic AI, on more than 9 trillion nucleotide sequences to learn DNA design rules, then used it to generate about 285 candidate viral genomes; 16 of these synthesized genomes assembled into viable bacteriophages that can infect and reproduce in E. coli, demonstrating AI’s potential to design new organisms while highlighting serious biosafety and governance concerns about applying such methods to pathogens.

Evolutionary Progression from Archaea to Phage in Z-Genome Biosynthesis.
science3 years ago

Evolutionary Progression from Archaea to Phage in Z-Genome Biosynthesis.

Researchers have discovered a third purine biosynthesis pathway in phages that replaces adenine with aminoadenine, a modification previously only found in Archaea. The pathway involves a novel enzyme, GpPurZ0, which catalyzes the conversion of IMP to 2-aminopurine ribonucleotide. The discovery suggests an evolutionary progression from Archaea to phages and expands our understanding of the diversity of DNA biosynthesis pathways.