Tag

Pharmacotherapy

All articles tagged with #pharmacotherapy

health1 month ago•4 min saved

After the Highest GLP-1 Dose: How to Sustain Weight Loss

Even at the highest GLP-1 dose, weight loss and health improvements can continue with a shift from calorie restriction to quality nutrition (protein, vegetables, fiber, hydration), plus regular resistance training to preserve muscle. Patients should closely monitor weight, cravings, satiety, and key labs (such as A1c) so clinicians can intervene early. If needed, plans may include tapering or spacing doses, switching medications, or considering minimally invasive surgery, all within an active, personalized maintenance program with ongoing follow-up and goal-directed care.

via Medscape|

#glp-1 #health #maintenance

health7 months ago•5 min saved

Epilepsy drug sulthiame trims sleep apnea events by up to 50% in trial

A European phase II trial with 240 adults showed that nightly 200–300 mg sulthiame reduced sleep-apnea severity by about 30–50% versus placebo, improving breathing interruptions and oxygenation with no major safety concerns. The results suggest a direct pharmacological approach to sleep-disordered breathing, though longer and broader studies are needed to confirm durability and safety beyond CPAP-centered care.

via ScienceAlert|

#clinical-trial #health #pharmacotherapy

health3 years ago•2 min saved

"Cytisinicline: A Promising Treatment for Smoking Cessation"

A randomized clinical trial involving 810 adults who smoked found that both a 6-week and a 12-week course of cytisinicline, a plant-based alkaloid, were more effective than placebo in promoting smoking cessation. The novel dosing regimen of cytisinicline, which binds to nicotine receptors, demonstrated higher continuous smoking abstinence rates during treatment and up to 24 weeks after treatment. The drug was well tolerated, with nausea, abnormal dreams, and insomnia being the most common side effects. This study suggests that cytisinicline, along with behavioral support, could be a new treatment option for nicotine dependence.

via JAMA Network|

#clinical-trial #cytisinicline #health

health3 years ago•5 min saved

Combining Cagrilintide and Semaglutide for Diabesity Prevention.

Coadministration of cagrilintide and semaglutide, dubbed CagriSema, resulted in significant weight loss and improved glucose control in a phase 2 trial of patients with type 2 diabetes. The combination drug had a synergistic effect for both glycemic control and weight loss, with a magnitude not previously reported with pharmacotherapies in this population. The study suggests that combination metabolic hormonal therapy could offer weight reduction, remission of type 2 diabetes, and reduced cardiovascular mortality in the near future. However, more patients are needed for further investigation in longer and larger phase 3 studies.

via Medscape|

#clinical-trial #diabetes #glucose-control