Ancient DNA refutes Medici poisoning theory, malaria blamed for Francesco I
Yale researchers used ancient DNA from Francesco I de' Medici and his brother Giovanni to test centuries-old poisoning rumors; they found genetic traces of Plasmodium falciparum and other malaria parasites in the remains, indicating Francesco’s 1587 death was likely due to malaria rather than poisoning and illustrating how genomic analysis can resolve historic mysteries and illuminate parasite evolution.