Preventive Therapy News

health1 month ago•4 min saved

New Migraine Prevention Guidelines Highlight CGRP Therapies and Personalization

The American Academy of Neurology and the American Headache Society released updated migraine prevention guidelines that incorporate CGRP-targeted therapies and emphasize individualized treatment decisions based on efficacy, tolerability, long-term safety, and cost for episodic and chronic migraine. The guideline expands recommendations to more patients (those with frequent migraine days) and outlines preferred options (atogepant, CGRP monoclonal antibodies, and onabotulinumtoxinA, alongside older meds like propranolol, topiramate, and valproate). It also provides guidance on trial duration (8–12 weeks for most meds, 24 weeks for onabotulinumtoxinA), pregnancy considerations, comorbidities, medication overuse, and nonpharmacologic approaches to optimize care.

via Medscape|

#cgrp #guidelines #health

science5 months ago•3 min saved

Brain Switch Uncovered That Could Prevent Alzheimer’s Memory Loss

UCSD researchers used an AI-driven approach to identify chromogranin A as a molecular switch deciding whether Alzheimer’s pathology translates into memory loss. In tauopathy mice, removing CgA preserved learning and memory despite brain pathology, with females showing stronger protection. They also found catestatin, a peptide derived from CgA, which lowered disease markers and protected cognition across several mouse models. All findings are preclinical and require replication, dosing, safety studies, and regulatory review before any human testing, but the work aims to shift Alzheimer’s research toward prevention-based strategies.

via Hoodline|

#alzheimers #catestatin #chromogranin-a

health3 years ago•7 min saved

Rare genetic mutation offers hope for Alzheimer's prevention

A man who carried a mutated gene called presenilin-1 (PSEN1) that almost certainly leads to Alzheimer's disease at a young age, defied his genetic odds and kept normal function for decades longer than he should have. Genetic analysis revealed that the man had a rare change in a gene that codes for a protein called reelin, which helps nerve cells communicate. The enhanced reelin protein seemed to be protecting a very specific part of the man's brain, an area that sits behind the nose at the base of the brain called the entorhinal cortex. Scientists say that understanding how this gene change defended his brain may help prevent Alzheimer's in other people.

via WCVB Boston|

#alzheimers-disease #entorhinal-cortex #genetics

health3 years ago•7 min saved

Rare genetic mutation offers hope for Alzheimer's prevention

A man who carried a mutated gene called presenilin-1 (PSEN1) that almost certainly leads to Alzheimer's disease at a young age, defied his genetic odds and kept normal function for decades longer than he should have. Genetic analysis revealed that the man had a rare change in a gene that codes for a protein called reelin, which helps nerve cells communicate. The enhanced reelin protein seemed to be protecting a very specific part of the man's brain, an area that sits behind the nose at the base of the brain called the entorhinal cortex. Scientists say that understanding how this gene change defended his brain may help prevent Alzheimer's in other people.

via KOCO Oklahoma City|

#alzheimers-disease #entorhinal-cortex #genetics

health3 years ago•7 min saved

Genetic Mutation Offers Hope for Alzheimer's Prevention and Treatment

A man who carried a mutated gene called presenilin-1 (PSEN1) that almost certainly leads to Alzheimer's disease at a young age, defied his genetic odds and kept normal function for decades longer than he should have. Genetic analysis revealed that the man had a rare change in a gene that codes for a protein called reelin, which helps nerve cells communicate. The enhanced reelin protein seemed to be protecting a very specific part of the man's brain, an area that sits behind the nose at the base of the brain called the entorhinal cortex. Scientists say that understanding how this gene change defended his brain may help prevent Alzheimer's in other people.

via WESH 2 Orlando|

#alzheimers-disease #entorhinal-cortex #genetics

health3 years ago•7 min saved

Genetic Mutation Offers Clue to Preventing Alzheimer's Disease.

A man who carried a mutated gene called presenilin-1 (PSEN1) that almost certainly leads to Alzheimer's disease at a young age, defied his genetic odds and kept normal function for decades longer than he should have. Genetic analysis revealed that the man had a rare change in a gene that codes for a protein called reelin, which helps nerve cells communicate. The enhanced reelin protein seemed to be protecting a very specific part of the man's brain, an area that sits behind the nose at the base of the brain called the entorhinal cortex. Scientists say that understanding how this gene change defended his brain may help prevent Alzheimer's in other people.

via KCCI Des Moines|

#alzheimers-disease #entorhinal-cortex #genetics