A Phase 1 trial in South Africa and Uganda found that the new HIV preventative drug Lenacapavir, administered as a biannual injection, achieved a 100% success rate in preventing HIV infections in women, outperforming two other existing PrEP drugs.
Pre-exposure prophylaxis (PrEP) and non-occupational post-exposure prophylaxis (nPEP) are two medication therapies that can help with prophylaxis against HIV. Truvada and Descovy are two FDA-approved medications for PrEP, with Apretude being another option. PrEP can help prevent the spread of the virus, especially if effectively taken every day. However, it may cause adverse effects such as diarrhea, nausea, headaches, fatigue, and stomach pain. Approximately 1.2 million adults are estimated to have an HIV risk high enough to warrant PrEP use and therapy, but only approximately 70,000 individuals have actively sought therapy from their providers.
Lyme disease cases have doubled in the last 20 years, and there are currently no vaccines available for humans. However, multiple vaccines are in development, including a prophylaxis shot that delivers antibodies directly to the vaccinated person. A vaccine by Pfizer and Valneva is in stage 3 clinical trials and could be ready for the next tick season. Experts recommend taking preventive measures, such as checking for ticks daily, wearing protective clothing, and using insect repellent.