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Lyme Disease

All articles tagged with #lyme disease

RFK Jr.'s Lyme pledge collides with vaccine history as Pfizer pushes a new jab
health11 days ago

RFK Jr.'s Lyme pledge collides with vaccine history as Pfizer pushes a new jab

RFK Jr., as HHS secretary, pledges stronger action on Lyme disease with better diagnostics and treatment, but his anti-vaccine stance complicates Pfizer/Valneva’s plan to file a Lyme vaccine—the first in more than two decades. The prior Lyme vaccine Lymerix faced safety questions and weak uptake, illustrating the challenges Pfizer now faces, even as Lyme incidence rises with climate-driven tick expansion and researchers pursue vaccines and other preventive tools.

via CNN|
#health#lyme-disease#lymerix
New Four-Dose Lyme Vaccine Shows About 70% Protection
health13 days ago

New Four-Dose Lyme Vaccine Shows About 70% Protection

Pfizer and Valneva announced phase 3 results for PF-0730740, a four-dose Lyme disease vaccine that achieved about 70% efficacy in preventing infection among people aged 5+ across the US, Canada, and Europe. The regimen requires four injections (two two months apart, then months five–nine, then one year later) and the vaccine is not yet approved; its impact on disease complications is unknown, but it could offer meaningful protection for those in endemic areas while continued tick-prevention steps remain important.

via Women's Health|
#health#lyme-disease#pfizer
Lyme Vaccine Delivers Promising 70%+ Protection in Major Trial, Heads to FDA Review
health17 days ago

Lyme Vaccine Delivers Promising 70%+ Protection in Major Trial, Heads to FDA Review

Pfizer and Valneva’s VALOR Phase III trial for PF-07307405 shows about 73% efficacy at preventing confirmed Lyme disease, but the primary endpoint's 95% confidence interval is wide (15.8%–93.5%), likely due to milder Lyme activity during the study; a separate analysis confirms the lower bound above 20%, supporting FDA-approval steps. The vaccine targets the OspA protein to block Borrelia burgdorferi in ticks, and if approved could significantly boost Lyme prevention for high-risk groups.

via Gizmodo|
#clinical-trial#health#lyme-disease
Lyme vaccine shows strong efficacy in late-stage results but misses primary endpoint
health19 days ago

Lyme vaccine shows strong efficacy in late-stage results but misses primary endpoint

Pfizer and Valneva's Lyme disease vaccine posted 73.2% efficacy starting 28 days after the fourth dose in a late-stage trial, but the study missed its primary endpoint under the worst-case scenario (15.8% efficacy in the initial analysis); a second analysis showed 74.8% efficacy, leading to plans for regulatory submissions, with no Lyme vaccine currently approved.

via NBC News|
#clinical-trial#health#lyme-disease
Pfizer pushes ahead with Lyme vaccine despite late-stage trial miss
business19 days ago

Pfizer pushes ahead with Lyme vaccine despite late-stage trial miss

Pfizer intends to seek FDA approval for its Lyme disease vaccine candidate even after a late-stage trial failed to meet statistical goals due to too few Lyme cases; the company says efficacy exceeded 70% in vaccine recipients versus placebo, which they consider strong enough to move forward. Partner Valneva projects up to $1 billion in peak annual sales. The Phase 3 study started with about 18,000 participants but was reduced to roughly 9,400 due to site-quality issues, and Pfizer reports no safety concerns; the vaccine requires three initial doses followed by a booster and targets the outer surface protein A of the bacteria.

via CNBC|
#business#lyme-disease#pfizer
Sex and menopause influence early Lyme disease signs, Johns Hopkins study shows
health1 month ago

Sex and menopause influence early Lyme disease signs, Johns Hopkins study shows

A Johns Hopkins Medicine study of 243 adults with early Lyme disease found sex- and menopause-related differences in presentation: men were more likely to test positive and show more severe disease at diagnosis, while certain symptoms were more common in women (heart palpitations, vomiting, light sensitivity) and sleep problems were more common in men, highlighting the need to consider sex and hormonal status in diagnosing and managing early Lyme disease.

via LymeDisease.org|
#diagnosis#early-symptoms#health
Lyme battle in New Jersey prompts a family to warn others
health1 month ago

Lyme battle in New Jersey prompts a family to warn others

A New Jersey man, Mike Gallagher, continues to struggle with lingering neurological symptoms from Lyme disease, unable to use his arms or play his guitar, prompting his community to hold a benefit concert to fund his ongoing treatment. Experts say rising tick populations in the Northeastern U.S.—driven by warmer temperatures—are increasing Lyme disease risk, underscoring prevention measures (protective clothing, repellents, tick checks) while scientists work on vaccines.

via Yahoo|
#health#lyme-disease#new-jersey
Infectious Disease Doctor's Experience Sitting Next to Vaccine Skeptic on Plane
health5 months ago

Infectious Disease Doctor's Experience Sitting Next to Vaccine Skeptic on Plane

An infectious disease doctor shares her experience of engaging in a respectful conversation with a vaccine skeptic on a plane, emphasizing the importance of dialogue in combating misinformation and conspiracy theories about diseases and vaccines, and highlighting the need for trust and understanding between scientists and the public.

via Yahoo News Australia|
#conspiracy-theories#covid-19#health
Rising Tick Threats and Lyme Disease Risks Amid Endemic Levels
health5 months ago

Rising Tick Threats and Lyme Disease Risks Amid Endemic Levels

Health officials in Ohio County, West Virginia, warn of endemic levels of Lyme disease, driven by rising global temperatures that expand tick habitats and prolong their activity, increasing human infection risk. The surge highlights how climate change is reshaping disease patterns, emphasizing the importance of early detection, prevention measures, and ongoing research for vaccines and diagnostics.

via Yahoo|
#climate-change#disease-prevention#health