Tag

Protein Sequences

All articles tagged with #protein sequences

"Revolutionary Deep Learning Techniques for Antiviral Medicine Discovery and ICU Prediction in COVID-19 Patients"
science-and-technology3 years ago

"Revolutionary Deep Learning Techniques for Antiviral Medicine Discovery and ICU Prediction in COVID-19 Patients"

Researchers have proposed a deep learning model called Deep-AVPiden, based on temporal convolutional networks (TCNs), for the classification and discovery of antiviral peptides (AVPs). The model outperforms existing classifiers and has a less compute and memory-intensive version called Deep-AVPiden (DS). A web app has been developed using both models to aid wet-lab researchers in discovering AVPs in protein sequences. The models were trained on a dataset of peptides collected from various sources and were compared using statistical analysis. The proposed models have shown promising results in identifying AVPs in proteins of plants, mammals, and fishes, with 15 AVPs proposed for chemical synthesis and experimental validation.

"Generative AI: From Antibodies to Productivity Boosts"
science-and-technology3 years ago

"Generative AI: From Antibodies to Productivity Boosts"

Generative artificial intelligence (AI) can suggest sequences that boost the potency of antibodies against viruses such as SARS-CoV-2 and ebolavirus, according to a study published in Nature Biotechnology. Researchers used neural networks called protein language models to suggest a small number of mutations for antibodies. The model was trained on only a few thousand antibody sequences, out of the nearly 100 million protein sequences it learnt from. Many of the suggested changes to antibodies occur outside the regions of the protein that interact with its target, which are usually the focus of engineering efforts.