Tag

Ptbp1

All articles tagged with #ptbp1

science1 month ago•171 min saved

Gel turns brain support cells into neurons, hinting at Alzheimer's therapy but still early-stage

Scientists report a polymer gel that carries a PTBP1-targeting antibody across the blood-brain barrier to astrocytes, converting them into neurons in cell cultures and brain organoids; in Alzheimer’s-model mice, this treatment correlated with more neurons, reduced inflammation, and improved memory in behavioral tests, though in vivo neuronal conversion remains unconfirmed and extensive safety and primate studies are still needed before any human trials.

via Live Science|

#alzheimers-disease #astrocytes #gel-therapy

science1 month ago•53 min saved

Two Injections Rebuild Brain Cells in Alzheimer's-Modeled Mice

USC researchers used a Nano-ERASER system to degrade PTBP1 in brain astrocytes, converting them into neurons in Alzheimer’s-model mice. After just two injections, treated mice showed higher neuron density, better performance on nest-building and water maze tasks, and reduced brain inflammation markers, indicating reversal of Alzheimer’s-like damage in these models. The findings are early-stage, demonstrated in mice and brain organoids, with primate and human trials still far off.

via Yahoo|

#alzheimers-disease #astrocytes #nano-eraser

science1 month ago•5 min saved

Two Injections Convert Brain Support Cells into Neurons, Reversing Alzheimer's Signs in Mice

Researchers at the University of South Carolina used Nano-ERASER, an injectable nanogel system that degrades PTBP1 in astrocytes, to trigger astrocyte-to-neuron conversion in brain organoids and Alzheimer’s-like mice. After two injections, treated mice showed improved nesting behavior and better performance in water maze tests, with higher neuron density and reduced disease markers, suggesting repair of neural circuits. While promising, the findings are early-stage and limited to animals; further long-term and primate studies are planned before any human trials.

via ScienceAlert|

#alzheimers-disease #astrocytes #nano-eraser