Massive trial finds beta blockers may be unnecessary after uncomplicated heart attacks
The REBOOT trial (8,505 patients, ~109 hospitals, ~4 years) found that beta blockers did not meaningfully reduce death, recurrent heart attack, or heart-failure hospitalization in patients who had an uncomplicated heart attack with preserved heart function, and a sex-specific analysis showed higher risk for women taking the drugs. This could push a shift toward more personalized post–heart attack care and reduce unnecessary prescriptions, though beta blockers may still be appropriate for patients with reduced function or other indications.
