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Spironolactone

All articles tagged with #spironolactone

SPIRIT-HF Finds No Clear Benefit of Spironolactone in HFpEF/HFmrEF
heart-failure13 days ago

SPIRIT-HF Finds No Clear Benefit of Spironolactone in HFpEF/HFmrEF

SPIRIT-HF found no meaningful reduction in the primary endpoint (HF hospitalizations or cardiovascular death at 24 months) with spironolactone in patients with HFpEF or HFmrEF. The spironolactone group had more total hospitalizations and adverse events (hypotension, renal issues, hyperkalemia). A high COVID-19–related discontinuation and limited power may have muted efficacy signals; a meta-analysis with TOPCAT also showed no significant benefit, though ongoing registries may clarify safety and efficacy.

"Blood Pressure Drug Emerges as Top Acne Treatment for Women"
health1 year ago

"Blood Pressure Drug Emerges as Top Acne Treatment for Women"

A generic high blood pressure drug, spironolactone, has become the most commonly prescribed oral medication for treating acne in women, surpassing antibiotics and birth control pills. This shift is influenced by guidelines to limit antibiotic use to combat drug resistance and growing evidence supporting spironolactone's safety and effectiveness. The rise in IUD use, which can lead to increased acne, also contributes to this trend.

"Dermatologists' Surprising Solution: Blood Pressure Drug Prescribed for Acne in Women"
health2 years ago

"Dermatologists' Surprising Solution: Blood Pressure Drug Prescribed for Acne in Women"

Dermatologists are increasingly prescribing spironolactone, a blood pressure medication, to women for treating acne, with prescribing rates rising nearly 300% from 2017 to 2020. The drug works by blocking hormones that cause acne, particularly in women, and is considered when other treatments like oral antibiotics or creams don't work. While spironolactone is generally safe, it's not FDA-approved for acne and has potential side effects, so more high-quality studies are needed to fully understand its long-term safety and efficacy.

"Spironolactone: The Surprising Solution for Acne"
health2 years ago

"Spironolactone: The Surprising Solution for Acne"

Dermatologists are increasingly prescribing spironolactone, a blood pressure medication, to women for treating acne due to its ability to block hormones that cause acne. The drug, which is not FDA-approved for acne, has seen a nearly 300% rise in prescribing rates for acne in women from 2017 to 2020. While spironolactone has shown effectiveness in treating acne, its long-term safety and potential side effects, including mild ones like breast tenderness and irregular bleeding, as well as more serious ones like potential impact on pregnancy and cancer risk, need further study. Despite these concerns, the American Academy of Dermatology is encouraging the limited use of antibiotics for acne treatment, potentially leading to increased use of spironolactone.