Tag

Hfpef

All articles tagged with #hfpef

science1 month ago•5 min saved

Urolithin A from Pomegranates Boosts Heart Relaxation in Lab HFpEF Models

Lab studies from King’s College London show that urolithin A, a compound produced after eating pomegranates, activates PKGIα to improve heart relaxation, reduce scar tissue, and limit heart-muscle enlargement in models of heart failure with preserved ejection fraction, with functional gains up to 80%. While promising, findings are in animals and engineered human tissue; human trials are needed and dietary strategies to raise urolithin A levels are being explored, not yet a proven treatment.

via SciTechDaily|

#heart-failure #hfpef #pkgia

health1 month ago•10 min saved

Pomegranate metabolite urolithin A improves heart relaxation in HFpEF models

Researchers found that urolithin A, a metabolite produced after eating pomegranates, improves heart relaxation and reduces harmful heart changes in models of heart failure with preserved ejection fraction (HFpEF) by activating the PKGIα pathway; the results in animals and engineered human heart tissue suggest a new therapeutic target, but human trials are needed and dietary pomegranate intake should not be seen as a treatment.

via News-Medical|

#health #heart-relaxation #hfpef

heart-failure6 months ago•13 min saved

SPIRIT-HF Finds No Clear Benefit of Spironolactone in HFpEF/HFmrEF

SPIRIT-HF found no meaningful reduction in the primary endpoint (HF hospitalizations or cardiovascular death at 24 months) with spironolactone in patients with HFpEF or HFmrEF. The spironolactone group had more total hospitalizations and adverse events (hypotension, renal issues, hyperkalemia). A high COVID-19–related discontinuation and limited power may have muted efficacy signals; a meta-analysis with TOPCAT also showed no significant benefit, though ongoing registries may clarify safety and efficacy.

via acc.org|

#heart-failure #hfmref #hfpef

health1 year ago•6 min saved

Internal Fat Identified as Key Cause of Heart Failure

A new theory suggests that signals from unhealthy fat tissue, rather than the heart itself, may be the primary cause of heart failure with preserved ejection fraction (HFpEF), highlighting the role of adipokines in inflammation, vascular stiffness, and scarring, and proposing new avenues for diagnosis and treatment.

via AOL.com|

#adipokine-hypothesis #fat-tissue-signals #health

health1 year ago•6 min saved

Internal Fat Identified as Key Cause of Heart Failure

A new study suggests that internal fat, through the release of harmful adipokines, may be the primary cause of heart failure with preserved ejection fraction (HFpEF), shifting the focus from traditional blood pressure causes to fat biology, and opening new avenues for diagnosis and treatment.

via The Brighter Side of News|

#adipokines #fat-tissue #health