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Hfpef

All articles tagged with #hfpef

Pomegranate metabolite urolithin A improves heart relaxation in HFpEF models
health4 days ago

Pomegranate metabolite urolithin A improves heart relaxation in HFpEF models

Researchers found that urolithin A, a metabolite produced after eating pomegranates, improves heart relaxation and reduces harmful heart changes in models of heart failure with preserved ejection fraction (HFpEF) by activating the PKGIα pathway; the results in animals and engineered human heart tissue suggest a new therapeutic target, but human trials are needed and dietary pomegranate intake should not be seen as a treatment.

via News-Medical|
#health#heart-relaxation#hfpef
SPIRIT-HF Finds No Clear Benefit of Spironolactone in HFpEF/HFmrEF
heart-failure4 months ago

SPIRIT-HF Finds No Clear Benefit of Spironolactone in HFpEF/HFmrEF

SPIRIT-HF found no meaningful reduction in the primary endpoint (HF hospitalizations or cardiovascular death at 24 months) with spironolactone in patients with HFpEF or HFmrEF. The spironolactone group had more total hospitalizations and adverse events (hypotension, renal issues, hyperkalemia). A high COVID-19–related discontinuation and limited power may have muted efficacy signals; a meta-analysis with TOPCAT also showed no significant benefit, though ongoing registries may clarify safety and efficacy.

via acc.org|
#heart-failure#hfmref#hfpef