All articles tagged with #stem cell transplant
A Preston, England woman says medics doubted her dizzy symptoms after illness, but blood tests revealed severe aplastic anemia, a rare and potentially fatal bone-marrow disorder. She now relies on regular transfusions and faces a stem-cell transplant; finding a donor—particularly from her ethnic background—is challenging, prompting a local donor-registration drive to boost matches.
Cardiff 24-year-old Caitlin Leggett’s AML has returned after remission and a stem cell transplant, and UK options are unlikely to be curative. She and her identical twin Grace, who cannot donate due to their near-identical DNA, are raising about £500,000 for potentially curative treatment abroad (US or CAR-T therapy) while continuing monitoring and trials. The twins only discovered they were identical after Caitlin’s diagnosis, and their fundraising aims to cover treatment and travel costs so they can face the future together.
A 63-year-old Norwegian man with HIV and myelodysplastic syndrome received a stem cell transplant from his brother, who carried the CCR5-delta-32 mutation that confers HIV resistance. Four years later, and two years after stopping antiretroviral therapy, HIV remains undetectable, suggesting a cure in this rare, high-risk procedure. This is the first HIV cure case with a family donor and one of roughly ten reported worldwide, underscoring that while groundbreaking, it is not a scalable treatment option.
An Oslo man with HIV and bone marrow cancer underwent an allogeneic stem cell transplant from his CCR5Δ32/Δ32 brother. The donor’s double mutation disabled a key HIV entry protein, enabling his new immune system to replace the patient’s. Two years post-transplant, the patient’s HIV is undetectable and he has stopped antiretroviral therapy without viral rebound, indicating a likely cure or sustained remission. The approach is rare, carries significant risks, and findings may guide future cures, but it is not scalable for general HIV treatment and requires further study.
A German man, Berlin 2, remains in HIV remission six years after a stem cell transplant from a donor with only one copy of the CCR5 Δ32 mutation, suggesting new avenues for HIV treatment beyond rare donor matches, and highlighting the potential of reservoir reduction and immune system rebuilding in achieving long-term remission.
A study from Ireland highlights the complex physical and emotional challenges faced by multiple sclerosis (MS) patients undergoing autologous hematopoietic stem cell transplant (HSCT). The research emphasizes the need for a comprehensive, multidisciplinary care approach to support patients throughout the treatment process. Interviews with 12 MS patients revealed themes of balancing hope and fear, emotional and physical recovery challenges, and adjusting to treatment outcomes. Despite varied experiences, most patients expressed no regrets about undergoing HSCT, though further research is needed to better understand patient perspectives and decision-making.
Beth Kitchin, a healthy dietitian and runner, initially mistook leg pain for a running injury, but an MRI revealed tumors, leading to a diagnosis of acute lymphoblastic leukemia. After undergoing intensive chemotherapy and a stem cell transplant, she faced complications but is now recovering and advocating for affordable medicine.
Johanna Mendoza, 22, was diagnosed with acute lymphocytic leukemia after developing red splotches on her skin while on vacation in Mexico. She needed a blood stem cell transplant and underwent chemotherapy. Despite her twin sister and half brother not being matches, a clinical trial quickly found a partial bone marrow match for her. The trial investigated post-transplant medication to prevent graft-versus-host disease, and Mendoza's successful transplant has made her cancer-free. Catherine Vega, a stranger who donated her stem cells, shares her experience to encourage others facing challenges.
A man in California, Paul Edmonds, has achieved remission from both acute myelogenous leukemia and HIV after receiving a stem cell transplant with HIV-resistant donor cells. This remarkable treatment, detailed in the New England Journal of Medicine, makes Edmonds only the fifth-known person in the world to achieve remission from both illnesses. His case demonstrates the potential for personalized treatments for older adults with blood cancers and HIV, offering hope for others living with these conditions.
68-year-old Paul Edmonds has been effectively cured of both HIV and leukemia following a breakthrough stem cell transplant in 2019, making him one of only five people in the world to achieve full remission of HIV. The transplant donor had a rare genetic mutation that makes people immune to most types of HIV, and Edmonds received the treatment at City of Hope in California. This success story offers hope for people living with HIV and leukemia, demonstrating the potential of stem cell transplants in treating these diseases.
Paul Edmonds, a 68-year-old patient, has been virtually healed of acute myelogenous leukaemia and is in remission for HIV after a transformative stem cell transplant at a California-based cancer treatment hospital. He is one of just five persons in the world to achieve complete remission from the virus, having carried HIV for over 31 years. This medical breakthrough follows the case of Timothy Ray Brown, the "Berlin patient," who became the first person to achieve HIV remission and cure himself of the virus and leukaemia through similar treatment.
Paul Edmonds, a 68-year-old man from California, is "extremely grateful" to be essentially cured of acute myelogenous leukemia and in HIV remission five years after receiving a stem cell transplant. He is one of only five people in the world to achieve full remission of HIV, having had the virus for over 31 years. The stem cells used in his transplant had a rare HIV-resistant gene mutation. Edmonds will be considered cured of HIV after ceasing antiretroviral therapy for five years. This success follows similar cases, including the "Berlin patient" and a New York woman, indicating progress in the treatment of HIV and leukemia through stem cell transplants.
A 68-year-old man, Paul Edmonds, expresses extreme gratitude after being essentially cured of acute myelogenous leukemia and achieving HIV remission following a stem cell transplant at City of Hope. He is one of only five people in the world to achieve full remission of HIV, having had the virus for over 31 years. This remarkable treatment marks a significant medical breakthrough, with Edmonds being the fifth and oldest person to be in remission for HIV.
A 68-year-old California man, Paul Edmonds, has been cured of both HIV and blood cancer after receiving a rare stem cell treatment. Diagnosed with AIDS in 1988, he underwent a stem cell transplant in 2019, which not only cured his leukemia but also rid his body of HIV. This makes him one of only five people worldwide to achieve HIV remission from a stem cell transplant. The medical team at City of Hope clinic in California is hopeful that personalized treatments for blood cancers, particularly in older patients with HIV, will become more common in the future.
Californian man Paul Edmonds, who had both cancer and HIV, has been free of both diseases since a stem cell transplant five years ago. The treatment has put him in remission from acute myelogenous leukemia and could potentially cure his HIV in another two years. The donated stem cells came with a genetic mutation that makes people resistant to HIV, and after the transplant, Edmonds showed no signs of either AML or HIV. This case has shown that older patients undergoing reduced-intensity conditioning HCT for cancer treatment may be cured of HIV-1 infection, but stem cell transplants come with substantial risks and are only viable for those with life-threatening blood cancers.