Tag

Syk

All articles tagged with #syk

health-and-medicine1 month ago•5 min saved

Blocking PTP1B Sparks Memory Gains and Plaque Clearance in Alzheimer's Model

Blocking the protein PTP1B improved learning and memory in a mouse model of Alzheimer's by boosting microglial clearance of amyloid-β plaques through enhanced SYK signaling; because PTP1B is also tied to obesity and diabetes, this approach could address multiple disease pathways and be combined with existing Alzheimer's treatments, with DepYmed, Inc. collaborating to develop the inhibitors.

via ScienceDaily|

#alzheimers-disease #amyloid-b #health-and-medicine

health3 months ago•6 min saved

Blocking PTP1B boosts brain cleanup and memory in Alzheimer’s mice

In a mouse model of Alzheimer’s disease, researchers found that inhibiting the brain enzyme PTP1B enhances microglial clearance of amyloid-beta by boosting SYK signaling, improving learning and memory. Because PTP1B is already a target for metabolic disorders, this approach could complement existing amyloid-clearing therapies and pave the way for combination treatments to slow disease progression.

via SciTechDaily|

#alzheimers-disease #amyloid-beta-clearance #health