SLE Neutrophils Generate Novel Neoantigens via Aberrant Splicing, Driving Autoimmunity
Researchers have identified a new mechanism for systemic lupus erythematosus (SLE) autoimmunity, where dysregulated mRNA splicing in neutrophils creates novel protein sequences. These 'cryptic' neoantigens are recognized by T and B cells, triggering clonal expansion and autoantibody production. The study confirms that 21 such peptides are presented on MHC molecules in SLE patients, linking innate immune cell dysfunction to adaptive immune activation.
