Tag

Vmat2

All articles tagged with #vmat2

Long COVID linked to dopamine nerve loss in the brain
science2 hours ago

Long COVID linked to dopamine nerve loss in the brain

A new eBioMedicine study finds long COVID patients show an average 18% reduction in dopamine-releasing nerve terminals in the striatum, measured by VMAT2 binding, with lower dopamine cell density correlating with apathy, slower motor speed, and memory issues; blood biomarkers did not reflect these brain changes. The authors suggest dopamine-enhancing treatments could help some patients, but note the study’s small, associative design and call for larger, longitudinal research to confirm causality and guide therapy.

Unraveling the Molecular Pathways of Neuronal Health and Drug Inhibition
neuroscience2 years ago

Unraveling the Molecular Pathways of Neuronal Health and Drug Inhibition

This article discusses the mechanisms of neurotransmitter transport and drug inhibition in human VMAT2 (vesicular monoamine transporter 2). It explores the structure and function of VMAT2, its role in monoamine neurotransmitter disorders, and the effects of drug inhibition on neurotransmitter storage and release. The article also highlights the clinical implications of VMAT2 inhibitors in the treatment of hyperkinetic movement disorders and refractory hypertension.