Tag

Dopamine

All articles tagged with #dopamine

health12 days ago•4 min saved

Triple-action ADHD drug centanafadine offers a new treatment option

Centanafadine (Simtriyo) is a US-approved ADHD medication for adults and children aged 6+ that uniquely increases dopamine, norepinephrine, and serotonin by blocking their reuptake. This triple-action approach differs from most stimulants, which mainly affect dopamine and norepinephrine, and has led to debate over whether centanafadine is a stimulant. In four phase-3 trials it improved ADHD symptoms versus placebo and was generally well tolerated, though no head-to-head comparisons with existing meds have been published. Common side effects include reduced appetite, insomnia, dry mouth, and headache, with a warning for suicidal thoughts. It is not yet approved in Australia, and research into its potential for ADHD with anxiety or depression is ongoing.

via theconversation.com|

#adhd #centanafadine #dopamine

health15 days ago•5 min saved

Long COVID Linked to 18% Drop in Brain Dopamine Nerve Endings, PET Study Finds

A small PET study (24 long COVID patients and 24 controls) found about an 18% reduction in dopamine nerve endings in the striatum of people with long COVID, with ventral striatum changes linked to lower motivation and dorsal striatum changes tied to slower movement and memory issues. The alterations persisted for up to 4.6 years after infection, suggesting the dopaminergic system as a potential biomarker for diagnosis and a target for treatment. The study’s sample is small, but researchers plan a clinical trial repurposing a dopamine-influencing drug, highlighting the need for validated long COVID therapies and better access to care.

via sciencealert.com|

#dopamine #health #long-covid

technology17 days ago•7 min saved

Dopamine 3.0 Brings the First iOS 26 Jailbreak for A12/A13 Devices

Dopamine 3.0 releases the first jailbreak for iOS 26, enabling jailbreaking on iOS 26.0 and 26.0.1 for devices with A12/A13 chips and broadening support to iOS 16.5.1 through iOS 17.3.1. AppleDB provides a full device-to-version compatibility breakdown.

via MacRumors|

#a12a13 #dopamine #ios-26

neuroscience18 days ago•5 min saved

Early Trauma Rewrites Brain Gene Activity in Dopamine Circuit

A mouse study in Neuron shows early-life stress increases the enzyme SETD7 in ventral tegmental area neurons, raising H3K4me1 marks and loosening DNA to prime dopamine-related genes for later activation. This makes animals more vulnerable to stress and anxiety, providing a potential biological mechanism for how childhood trauma increases mental-health risk and highlighting epigenetic targets for interventions, though human validation is needed; positive experiences might offer protective effects.

via ScienceAlert|

#dopamine #early-life-adversity #epigenetics

technology20 days ago•17 min saved

Lively feeds, heavier hearts: how social media fuels obsessive romance

A Washington Post feature explains how social media feeds intensify limerence, a consuming and idealized form of romantic obsession, by delivering constant validation, tailored glimpses of possible partners, and dopamine-driven feedback loops that blur reality and deepen fixation.

via The Washington Post|

#dopamine #limerence #psychology

science25 days ago•37 min saved

Long COVID linked to dopamine nerve loss in the brain

A new eBioMedicine study finds long COVID patients show an average 18% reduction in dopamine-releasing nerve terminals in the striatum, measured by VMAT2 binding, with lower dopamine cell density correlating with apathy, slower motor speed, and memory issues; blood biomarkers did not reflect these brain changes. The authors suggest dopamine-enhancing treatments could help some patients, but note the study’s small, associative design and call for larger, longitudinal research to confirm causality and guide therapy.

via psypost.org|

#brain-imaging #dopamine #long-covid

health1 month ago•5 min saved

Midlife Brain Fog: Distinguishing ADHD from Perimenopause

The article explains that midlife brain fog can be caused by hormonal changes during perimenopause or by ADHD, with estrogen and dopamine playing key roles in mood, sleep, memory and focus. ADHD typically begins in childhood, while perimenopause-related cognitive changes appear later, but the two can overlap or even be present together. For those unsure, tracking symptoms over weeks (including pattern across cycles, sleep, work and home life) and discussing detailed examples with a clinician can help determine whether ADHD, perimenopause, or both, warrants specific support.

via Flow Space|

#adhd #brain-fog #dopamine

science1 month ago•2 min saved

Light Awakens the Darkness: Blind Cavefish Move More in Illumination

Florida Atlantic University researchers found that the blind Mexican cavefish become more active when exposed to light, a light-evoked photokinesis opposite to surface fish, driven by dopamine signaling and repurposed brain circuits; the behavior appears heritable, offering insights into brain evolution and potential relevance to human neurological conditions.

via BBC Wildlife Magazine|

#cavefish #dopamine #evolution

neuroimaging2 months ago•27 min saved

Dopamine Keeps Stress-Reduced Courtship Alive in Fruit Flies

New research shows male Drosophila confined in tiny spaces exhibit a lasting drop in courtship after stress, and dopamine release is required to maintain this suppression. Blocking dopamine synthesis or signaling—via drugs, RNA interference, or removing receptors in the mushroom body—and silencing key dopamine neuron clusters (PAM and PPL1) prevents the prolonged reduction, though the immediate decline occurs without dopamine. Longer confinement (7–24 hours) yields suppression lasting days, highlighting a dopamine-dependent mechanism linking stress to reduced mating drive in fruit flies.

via PsyPost|

#courtship #dopamine #drosophila

health2 months ago•5 min saved

The Viral ‘Sad Nipples’ Phenomenon Explained: A Possible Hormonal Trigger for Sudden Blues

A viral TikTok wave describes sudden sadness, dread, or guilt triggered by nipple stimulation in some non-lactating women. Experts say oxytocin fluctuations and possibly dopamine drops could explain the emotional reactions, with parallels to the breastfeeding-related D-MER. The phenomenon is not formally recognized, research is limited, and sufferers are advised to identify triggers, practice relaxation, and consider cognitive behavioral therapy for persistent symptoms.

via The Daily Beast|

#d-mer #dopamine #health

health2 months ago•4 min saved

Nipple stimulation can spark sudden sadness—what 'sad nipple syndrome' really is

Doctors say that 'sad nipple syndrome' is a hormonal reflex where nipple stimulation triggers a rapid dopamine dip and oxytocin surge, provoking a brief wave of sadness or overwhelm that can occur in both lactating and some non‑lactating women; it’s a physiological response rather than a mental health disorder, and if it disrupts daily life, approaches like cognitive behavioral therapy may help.

via New York Post|

#breastfeeding #d-mer #dopamine

science2 months ago•9 min saved

Low-Dopamine Teens Drive the ‘Youth Peak’ in Substance Use, Study Finds

A longitudinal study of over 800 youths tracked for up to nine years finds that early experimentation with alcohol, cannabis, and nicotine is driven by a low baseline dopamine system rather than excess dopamine. Using brain tissue iron as a proxy for dopamine, researchers identified a distinct “youth-peak” group whose low dopamine levels predicted increased substance use in early adolescence that sharply declined as dopamine networks matured into adulthood. This challenges the idea that higher dopamine drives teen risk, suggesting most teen experimentation is a normal, temporary phase, and highlighting potential prevention approaches that channel risk-taking into healthy outlets; the study also notes digital environments may provide a modern alternative reward channel.

via Neuroscience News|

#adolescence #brain-imaging #dopamine

science2 months ago•6 min saved

Teen Cannabis Use Linked to Disrupted Brain Reward Development

A Brown University-led study with 81 adolescents (14–17) found that repeated cannabis use, especially high-potency products, correlates with lower brain tissue iron in dopamine-rich regions, signaling disrupted maturation of the dopamine system and reward processing. This first-of-its-kind MRI work suggests reduced dopamine-related neurophysiology in teens who use cannabis and highlights potential increased addiction vulnerability, warranting longitudinal follow-up to assess long-term outcomes.

via Neuroscience News|

#adolescence #brain-imaging #cannabis

health2 months ago•5 min saved

Giggles as Clues to the Developing Baby Brain

New research suggests infant laughter is a meaningful marker of healthy brain development and social bonding: involuntary laughter appears around 3–4 months and voluntary laughter emerges by about 6 months as motor and speech areas mature. Shared laughter boosts oxytocin and dopamine, supports regulation of stress, and helps clinicians gauge typical development. Parental stress and tech-heavy distractions can dampen these interactions, highlighting the need for supportive, distraction-free environments for families.

via Medscape|

#brain-development #dopamine #health

neuroscience2 months ago•7 min saved

Dopamine Sets the Pace of Stress-Driven Courtship Suppression in Flies

In fruit flies, researchers show that dopamine does not trigger the initial shutdown of mating drive under stress but acts as a molecular timer that sustains suppression after stress; longer confinement leads to longer-lasting courtship inhibition via dopamine signaling in the mushroom body, offering insights into stress-related sexual dysfunction that may extend to humans.

via Neuroscience News|

#dopamine #drosophila #mushroom-body