New daily pill may lock in weight loss after obesity injections
TL;DR Summary
A new daily pill, orforglipron, could help people maintain weight loss after stopping GLP-1 obesity injections. In a Nature Medicine trial, participants who took orforglipron for a year kept more than 70% of their earlier weight loss, versus about 38-50% for those on placebo; side effects were mostly mild. The long-term durability, duration of treatment, and cost (UK pricing not yet known) remain unclear, but experts say this supports the view that obesity is a chronic condition requiring ongoing management.
- Daily pill to help keep weight off after stopping obesity jabs BBC
- Orforglipron for maintenance of body weight reduction: the double-blind, randomized phase 3b ATTAIN-MAINTAIN trial Nature
- Lilly's Foundayo and lower-dose Zepbound helped people maintain weight loss after switching from higher doses of injectable incretin therapy in two late-phase trials investor.lilly.com
- Oral Orforglipron Effective in Older Adults With Obesity Medscape
- Daily pill can help people maintain weight loss after they come off jabs, trial shows The Guardian
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